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. shaadi mein laddoo deewana · k93n na1 kansai chiharu.rargolkes · (PRODUCTS) v3.2.1 RESULT REPAIR. · FOR.Isonomeric Core-Shell Nanoparticles with Differential Thermal Stability for Dual-Target Drug Delivery.
We synthesized core-shell isomeric poly(acrylic acid-co-allylcysteamine) (PAA-cys) nanoparticles loaded with thermally sensitive docetaxel (Dtxl) as a dual-targeting system for cancer treatment. Dtxl was entrapped within the hydrophobic core region of the PAA-cys nanoparticles through thermal denaturation of the cys moieties at about 80 °C. The nanoparticles showed different drug release patterns at the different temperatures of 50 and 80 °C, thereby increasing the treatment efficacy of the PAA-cys nanoparticles in two ways. First, because of the different decomposition temperatures of PAA and PAA-cys nanoparticles, the rate of Dtxl release from the former is slower, resulting in a prolonged exposure of Dtxl in the target site. Second, Dtxl loaded in the hydrophobic core region of the PAA-cys nanoparticles showed a faster drug release from the PAA-cys nanoparticles compared to the control nanoparticles, resulting in an additional enhancement of the therapeutic efficacy. In conclusion, PAA-cys nanoparticles are a promising platform for the delivery of two types of chemotherapeutic drugs.Tiberin
Tiberin (, ) is a village located west of Ratibor, in eastern Slovenia. It remains an independent settlement. The village is part of the traditional region of Styria and is now included in the Drava Statistical Region.
Geography
The village lies on the northern edge of the Slovene Hills () in the valley of the Rovtepec Creek. The area is hilly and flat, with a soil classified as loess. The elevation of the village ranges from about at the Jelovica meadow () and on the Mastora () plateau to about at the Gerlach meadow () and at
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