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Image-guided biopsies are performed as the mainstay for the diagnosis of solid intraosseous tumors. The utility and complications of these procedures are well known. New and alternative technologies such as an 11-gauge biopsy gun have recently been introduced in clinical practice. The aim of the study was to determine the utility and complications of percutaneous CT-guided bone biopsies of intraosseous tumors using a biopsy gun. Forty-eight patients referred for CT-guided bone biopsies of intraosseous neoplasms were included in this prospective study. A single radiologist performed all biopsies using the same procedure. A mechanical biopsy gun (Exactech, Gainesville, FL, USA) was inserted through a low-dose 16-multidetector CT (MDCT) scanner (Somatom Sensation 16, Siemens, Germany). The biopsy gun was activated and fired after the needle was advanced toward the tumor. Parameters including success rate, number of biopsies performed, and complications were recorded. Biopsies were performed successfully in every patient and successful biopsies included 18